No, not at the low ketone body levels observed in KEN™. Ketone bodies and the resultant acidosis become dangerous only with the high levels observed in patients with inadequate insulin response, as in uncompensated diabetes. Non-diabetics with intact insulin response do not reach the high levels of ketone bodies seen in diabetics and diabetic ketoacidosis (DKA).
An increase in blood ketone bodies, ketonemia, is observed whenever body fat is catabolized. When the catabolism of fat is slow, the increase in ketone bodies is slight. When the catabolism of fat is rapid, the increase in ketone bodies is significant and metabolic acidosis occurs. In the normal non-diabietic patient, ketonemia stimulates insulin production, slowing the mobilization of fat and preventing ketonemia from rising dangerously. The ketonemia becomes dangerous only when it occurs in patients with reduced insulin response, as in uncompensated diabetes. The slight ketonemia of KEN™ is helpful during the weight loss program because it reduces the appetite for food and so increases patient tolerance of the KEN™ fast.
Prolonged ketogenic diets are used safely in refractory epileptic patients. In such cases there is no risk to health and brain activity, such as cognitive abilities or task performance, such as driving a car.