The KEN™ is the treatment of obesity and overweight fastest and safest in the world.
Today, in our busy world, with such high prevalence of obesity, people seeking weight loss will not endure the classic low-calorie diets that lose only a few pounds a month. Dieters want to lose their weight quickly and see results day by day.
How do you lose weight quickly? Rapid weight loss is achieved by significant negative caloric balance: patients must burn significantly more calories than consuming. Complete fasting would be expected to be the best method to lose weight, but is not feasible for 2 reasons: 1) complete fasting generates such an irresistible hunger that dieters succumb to the temptation to eat and 2) significant loss of muscle mass. A healthy diet is expected to lose fat mass, not muscle mass.
In 1973, George Blackburn, a researcher at MIT subjected two groups of patients to complete fasting. Group A was continuously infused with 5% glucose solution; group B was continuously infused instead with a protein-sparing solution of amino acids. Group A had a significant negative nitrogen balance, while Group B had neutral or only slightly negative nitrogen balance. Such protein sparing allowed safer rapid weight loss in obese subjects. He designed a protein only diet, the Protein Sparing Modified Fast or “PSMF,” a diet administered by mouth and only during waking hours. The PSMF had two major drawbacks:
a. Oral dietary intake could not completely eliminate carbohydrates and the presence of carbohydrates stimulated insulin release.
b. Oral dietary intake was necessarily interrupted during the night.
The interruption of nutrition during the night is normal human eating behavior and does not cause a breakdown of lean body mass because the reserves of liver glycogen sustain caloric needs at night. During the night liver glycogen is rapidly depleted, so the body uses the dieter’s lean body mass as a source of calories.
For these reasons, PSMF obtained only a partial protein sparing with suboptimal weight loss and suboptimal conservation of lean mass. Optimal weight loss demanded extending the ketogenic diet, but cardiac arrests occurred while on prolonged PSMF dieting, a complication attributed to cardiac atrophy.
Ketogenic Enteral Nutrition (KEN) was conceived and developed to optimize weight loss while reducing or eliminating complications. KEN replaces the original oral protein sparing diet with a protein sparing parenteral infusion unavailable at the time of Blackburn’s first experiments. Continuous parenteral infusion obtains much faster weight loss and with less lean body loss. For best results and to avoid cardiac complications, the KEN cycle is limited to 10 days. In one 10-day cycle, patients typically lose 7 to 10% of initial weight. At least 57% of the weight lost is fat.