To avoid the reduced weight loss observed when KEN™ is continued beyond 10 days, there is a rest period during which the patient resumes controlled oral feedings.
After 10 days of KEN’s marked sustained reduction in caloric intake, body metabolism shifts towards a series of homeostatic defense mechanisms that cause markedly lower energy expenditure—reduction of general motility, decreased heart rate, and a tendency to stupor. To abort the counter-productive lower energy expenditure, a 2 week rest period of resumed controlled oral feedings is interposed between cycles of KEN™. The 2 week rest period is sufficient to reacquire the original rapid weight loss response when KEN#8482; is resumed.
Limiting KEN™ cycles to 10 days also serves to avoid the risk of cardiac complications that were observed with PSMF diets. In final analysis, the reported PSMF cardiac arrests were attributed to the use of a solution of improperly balanced protein (the “last chance diet”), not a comprehensive formulation of amino acids as was claimed.
KEN™ uses improved protein formulations that are complete and balanced. The improved formulation allows KEN™ to be used even continuously for months at a time without any side effects whatsoever. Rest periods were instituted to optimize rapid weight loss and to increase patient satisfaction and acceptance. Patient satisfaction and net weight loss are greater with a series of 10-day KEN cycles than with continuous KEN™. The rest periods provide a psychological relief to the patient who can return to a normal life. Rest periods are utilized to train the patient in developing dietary and lifestyle modifications necessary to manage weight once the treatment is discontinued.