Ketogenic enteral Nutrition as a treatment for obesity: Short term and Long term results from 19,000 patients
Gianfranco Cappello*, Antonella Franceschellim Annalisa Cappello and Paolo De Luca
Clinical Nutrition Service of the Department of Surgery Paride Stefanini, University of Rome La Sapienze, Rome, Italy
Nutrition & Metabolism 2012, 9:96 doi:10.1186/1743-7075-9-96 © 2012 Cappello et al.; licencsee BioMed Central Ltd.
Only protein diet has been used successfully to prevent loss of lean body mass first in post-surgical and then in obese patients. We studied overweight and obese patients receiving short treatments of an exclusively protein-based nutritional solution as 24-hours enteral infusion.
19,036 patients age 44.3±13, M:F = 2:5) with an initial body mass index of 36.5 ± 7.1 inderwent 10-day cycles of enteral nutrition through a fine nasogastric tube. The nutritional solution consisted solely of 50-65g of proteins, plus vitamins and electrolytes. The 24-hour infusion was controlled with a small portable pump. Before and after each 10-day cycle body composition was checked with a Handy 3000 impedance analyzer. At the onset of treatment, average fat mass was 40.9 ± 12.8Kg while body cell mass was 42.7 ± 7.2Kg in males and 27.4 ± 4.6Kg in females.
After an average of 2.5 cycles the patients lost 10.2 ± 7.0Kg of body weight., 5.8 ± 5.5Kg of fat mass and 2.2 ± 3.3Kg of body cell mass. No significant adverse effects were recorded except asthenia and constipation which were easily controlled with therapy. Long-term results were obtained from 15,444 patients and after an average of 362 ± 296 days we found a mean weight regain of 15.4%.
Ketogenic Enteral Nutrition treatment of over 19,000 patients induced a rapid 10% weight loss 57% of which was Fat Mass. No Significant adverse effects were found. The treatment is safe, fast, and inexpensive and has good one-year results for weight maintenance.
The KEN program founded in Italy and proven effective by over 57,000 participants, is a non-surgical procedure that feeds the body 24 hours a day for 10 days. This “Protein sparing” nutritional is a serious works like no other, targeting fat while preserving lean body mass. Ketogenic Enteral Nutrition is a serious, non-surgical, low cost solution. It is not a vanity product designed to make users look glamorous, it’s for obese men and women who need real help and achievable, healthy outcomes. KEN is looking for physicians with patients who are not yet fit enough for surgery or for whom surgery is not the best option.
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