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Using Genetics for Personalized Nutrition and Diet:
Genetics plays an important role in the absorption of nutrients from our food, the way food is metabolized and the amount of energy that is generated from the food we eat. This section will talk about your genome signature, its influence on your diet, food intolerances or allergies you might be susceptible to and more. Further, dietary recommendations or prescriptions will be given considering your unique genomic signature.
Genetics of Physical Performance (Sports and Fitness):
This panel is meant to enable you with DNA insights that are your personal compass to optimize your athletic training, performance and wellness. With traits covering muscular ﬁtness, recovery, and power/endurance training, it provides a comprehensive audit of your fitness genetics. Empower yourself with this information and ﬁnd out how you are made for more.
Response to toxins:
On a daily basis, we are exposed to many different toxic compounds, which the body is usually able to transform and eliminate through urine or feces. This process of "detoxification" is generally maintained by a set of enzymes and proteins, and hence are determined by your genomic signatures. Evaluating your genome for variants associated with these enzymes, may reveal an increased risk of impaired detoxification. More importantly, based on these indications, one can recommend foods that generally improve the efficiency of detoxification, which can aid you in coping with any impaired detoxification process.
Influence of Genetics on your Sleep Pattern:
The lifestyle covers many aspects of our daily life, but we focus mainly on your sleep pattern and response to stress. A recent genome-wide analysis of sleep duration, timing, and disturbances found that there was an overlap between sleep quality and the genetic variants that are associated with sleep disorders. We screen these variants to know your preference of sleep time or adaptability to sleep deprivation etc.
Genetics and aging:
Aging is an inevitable process. However most of us misunderstand it to mean the aches and pains that come with getting older. It actually is a series of processes that include DNA damage, accumulation of cellular waste, errors and imperfect repairs as well as the responses to them. These processes result in the familiar signs of aging and ultimately in the development of age-related diseases. Researchers have identified many genetic markers associated with expedition of aging process and increase in age-related disease susceptibility. This panel deals with such biomarkers and lets you know of any change in lifestyle or nutrition that can counter the aging process.
Genetics and substance addiction:
The chances of your initial use and the probability of progression toward an addictive pattern is known to be influenced by your genetics and other factors like sex, age, preexisting addictive disorder etc. The genetic signatures play a salient role in the transition to problematic addictiveness to addictive agents such as drugs, foods, sex, video-gaming, and gambling.
Genetic Risk of Diseases:
Every individual is unique and your genomic analysis can show how unique you are. Genetic predisposition increases/decreases the likelihood of you developing a specific disease. To ease the process of understanding your risk factors to various diseases, we have assessed these disease risks into categories of organ systems.
Genetic Risk of Cardiovascular Disease:
Your cardiovascular system is comprised of your heart and blood vessels. Cardiovascular disease (CVD) can manifest as complications to heart itself or as issues with blood vessels like CAD, Stroke, Heart failure etc. Risk of developing CVD is determined by a combination of genetics and environmental factors. The genetic aspect of CVD depends on what kind of information your DNA contains, especially in the genes related to heart development, lipid processing and blood pressure regulation. This panel helps you to estimate risk associated with CVDs and recommend a change in lifestyle and diet for healthy heart.
Genetics of Personality Traits:
Behavioral genetics has shown that there is significant heritability for personality traits. An understanding of the genetic variants you carry will help in understanding yourself better and in enhancing and developing aspects of your personality. In this panel, we profile genes that have been shown to influence personality traits like leadership potential, impulsivity, extroversion, entrepreneurship, and several other attributes relevant to innate character and personality.
Genetics for Personalized Skincare:
It is believed that changes in the skinʼs appearance (wrinkles, fine lines, dullness, age spots) are a function of changes in basic biological and physiological processes of skin cells, which, in turn, are regulated by your genes along with environmental effects. This also indicates how your skin reacts to any skin care product or ingredient. Through this panel, you can either create custom cosmetic products or avoid/completely stop using such products, based on an individualʼs genomic data.
Genetics and susceptibility to various Allergies:
Numerous genome-wide studies have reported linkage or association between genes and allergies such as peanut, egg, mold, pollen allergy. Although the root cause of such allergic reactions is unknown, it is generally attributed to the interactions between many genes and the environment. Other than causing the allergies, genetics may also contribute to as much as 60–80% of the variability in therapeutic response to allergy medications. Hence, it is very critical to know these underlying allergies you might be susceptible to.
BRCA Gene and Breast Cancer Risk:
The BRCA1 gene contains instructions for making a protein that helps repair damaged DNA. The BRCA1 protein also helps control the process of cell division. Through both of these functions, the BRCA1 protein acts as a tumor suppressor, preventing cells from growing and dividing too rapidly. Certain variants in the BRCA1 gene disrupt the protein's function. This can lead to a buildup of DNA errors and can cause normal cells to become cancer cells. Mostly, BRCA gene variants are associated with breast cancer, ovary cancer, and prostate cancer. We screen all the reported pathogenic variants in this panel and calculate the susceptibility to cancer.
Carrier status for Inherited Diseases:
Carrier screening is a type of genetic test that can tell you whether you carry a gene for certain genetic disorders. When it is done before or during pregnancy, it allows you to find out your chances of having a child with a genetic disorder. Prior knowledge of the risk of any genetic condition can prompt the physician to take various precautionary measures.
Pharmacogenomics for Precision Medicine:
The comprehension of genomic signatures is not limited to just diseases but extends further to an individualʼs response to certain drugs/therapies, prescribed during an illness. The utility of identifying such variants determines which drugs/therapies you may respond well to, or be resistant to or might be sensitive to and have unwanted side effects to. Previous knowledge of your pharmacogenomics can bring the attention of your physician and he/she can prescribe you alternate drug.
Methylation and Cardiovascular risk:
The Methylenetetrahydrofolate reductase (MTHFR) gene codes for a key enzyme that your body needs in order to use folate in the methylation cycle. The methylation pathway is a central biochemical process that impacts many of our cellular functions like DNA repair, protein modification, neurotransmitters production and detoxification of environmental toxicants. In this panel, we screen variants within MTHFR gene to assess the risk of methylation-related diseases and the need of folate supplement.